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Is It Safe to Mix LSD and Alcohol?

Mixing LSD — or any other drug for that matter — with alcohol is never recommended. That said, LSD and alcohol aren’t necessarily a life-threatening combo as long as you steer clear of heavy doses of either.

Healthline does not endorse the use of any illegal substances, and we recognize abstaining from them is always the safest approach. However, we believe in providing accessible and accurate information to reduce the harm that can occur when using.

When you combine LSD and alcohol, it reduces the effects of both substances. This may sound like a good thing if you’re looking to chill out or come down from an especially bad trip, but it’s not that simple.

When you aren’t feeling the effects of either substance as strongly, you’re more likely to reach for more, which can increase your risk of overdoing it with either substance.

Folks who’ve tried this combo report a bit of an unpredictable experience. Some people find it makes for a happier, more uplifting trip. Others, though, report having very strange trips or just vomiting like crazy.

As with any substance, how you’ll react depends on factors like:

  • how much of each you ingest
  • whether or not you’ve eaten
  • your body size and composition
  • any other medications you may be taking
  • preexisting physical and mental health conditions
  • tolerance to either LSD or alcohol
  • your surroundings

All substances come with risks — and LSD and alcohol are no different.

Mixing LSD with alcohol lowers the perceived effects of alcohol, which increases your risk of drinking too much. This can make you more vulnerable to the usual risks of alcohol, including alcohol poisoning or a nasty hangover.

Speaking of hangovers, mixing LSD and alcohol increases the potential for a rough comedown that can include nausea and vomiting, according to people who’ve been there, done that, and shared it online.

There’s also always the possibility of having a bad trip when you take LSD. Adding alcohol into the equation can make a bad trip worse and potentially make you aggressive, hostile, or even violent.

Before using any substance, it’s important to consider how it might interact with other substances you use or medications you take.

Other recreational substances

Not every substance has been studied for potential interaction with LSD, so it’s impossible to predict the outcome of combining LSD with other substances you may be taking.

We do know, however, that mixing any of the following substances with LSD can result in increased effects of both substances:

  • DMT
  • DXM
  • ketamine
  • MDMA
  • mushrooms

Mixing LSD with cocaine or cannabis can cause overstimulation and physical discomfort, depending on how much you use. Generally, the more you use of either substances with LSD, the more discomfort you’ll experience.

Prescription medication

LSD can also lessen the effect of certain medications, preventing them from working properly.

Some of these drugs include:

Again, it’s generally best to avoid mixing alcohol with other substances. Interactions can be unpredictable and are never exactly the same for two people.

If you’re still planning to combine the two, there are some precautions you can take to make the process a bit safer.

  • Having a trip-sitter. A trip-sitter is someone who stays with you and looks after you during a trip. Your cat doesn’t count. They should be someone you trust and who will stay sober the entire time in case you need help. Ideally, it should be someone who has experience with psychedelics and can spot the signs of a bad trip in the making or signs of an overdose.
  • Doing it somewhere safe. You should always be in a safe and comfortable place when tripping.
  • Limiting your alcohol intake. Since the risk of drinking too much is higher when you mix LSD and booze, you’ll want to find a way to limit your drinks. Keep just a small amount of alcohol with you, or go somewhere with limited access to alcohol. Also, tell your trip-sitter to stop you at a certain number of drinks.
  • Minding your dosing. Taking the right dose is key when using acid. Taking too much increases the risk of negative effects whether you’re drinking or not. Give the LSD time to kick in before adding alcohol to the mix or redosing.
  • Staying hydrated. Sipping water can help you stay hydrated. Too much alcohol can cause dehydration and psychedelic drugs increase body temperature, which can also be dehydrating. Water can help you pace your drinking and help reduce hangover and comedown symptoms. Having a few crackers on hand to help settle your stomach and slow the absorption of alcohol into your bloodstream is a good idea, too.
  • Considering your mood. Your chances of a bad trip are a lot higher if you take LSD while your head’s in a negative space. Also, alcohol is a depressant, so combining the two when you’re already feeling down will just further bring you down.

When to get help

If you or someone experiences any of the following while using LSD, alcohol, or other substances, call 911 right away:

  • irregular or shallow breathing
  • irregular heart rate
  • confusion
  • convulsions
  • hallucinations or delusions
  • seizure
  • loss of consciousness

If you’re concerned about law enforcement getting involved, you don’t need to mention the substances used over the phone. Just be sure to tell them about specific symptoms so they can send the appropriate response.

If you’re caring for someone else, get them to lay slightly on their side while you wait. Have them bend their top knee inward if they can for added support. This position will keep their airways open in case they begin to vomit.

Mixing LSD and alcohol can result in a not-so-pleasant trip and comedown.

What Happens When You Add Other Drugs To Your LSD Trip?

Some drugs just pair well together: coffee and cigarettes, alcohol and cocaine, weed and … pretty much anything. But what happens when you mix other drugs with that infamous sidewinder, LSD?

Tripping on acid can be one of the most profound experiences in some people’s lives. Just a tiny speck of LSD (scientifically known as lysergic acid diethylamide) will trigger an experience that can last 12 hours, depending on the dose and purity. It gives users a teeth-rattling “trip” packed with amplified colors that ripple and flow across their distorted perception of time and space. Ego, or the sense of self, can disintegrate into the soul’s ectoplasmic goo.

Although the drug itself is largely non-toxic, even at extremely high doses, tripping is not without risks. It can put users in dangerous physical situations. Most stories of people jumping or falling off buildings on acid are urban legends, but there are some rare case reports of people dying this way. LSD can trigger a psychotic episode and, very rarely, cause long-term mental changes, such as a condition known as hallucinogen perception persisting disorder. For better or worse, LSD is growing in popularity, which means it’s likely more people are combining acid with other drugs.

LSD and MDMA

One of the most common mixtures, popular since at least the early ‘80s, is “candyflipping,” or mixing LSD and MDMA, also known as “ecstasy” or “Molly.” Effects vary, but many users report this combo gives overwhelming feelings of unbridled euphoria from the MDMA, on top of the weird wonderment from LSD. Some users who have combined these two substances say the effects of MDMA, which typically last about four hours, also seem to be extended by the acid.

What Happens When You Mix Xanax and Alcohol?

This combo is often sought at raves, with users attempting to get both drugs to “peak” at the same time, usually by taking the MDMA several hours after the LSD kicks in, as they both have different zeniths. Yet, we don’t know much about how physically safe this combination is. There’s limited hard data on LSD and MDMA combos—or any other drug mixed with acid – because research for this kind of thing is extremely expensive and the ethics can be sticky.

“Combining LSD or another psychedelic with MDMA produces a particularly intense trip. The combination has stronger effects than you’d expect from the individual drugs,” said Matthew Baggott, a neuroscientist who studies the pharmacology of psychedelics. “Unfortunately, the combination also increases the toxic effects of MDMA, including on the neurons that make serotonin. Too much dopamine release in a brain that’s already working overtime can produce a lot of oxidative stress [an imbalance in body chemicals that can lead to cell and tissue damage].”

LSD and other psychedelics

LSD and the “classic” psychedelics all share one thing in common: their molecules very closely resemble the neurotransmitter serotonin, which has an impact on mood, perception, appetite and more.

“You can think of it like dance moves. Psychedelics dance with the serotonin receptor and remind it of certain moves that it had forgotten,” Baggott said. “Next, messenger molecules inside the cell copy the moves and the whole party changes. Different psychedelics have different dance moves. And they dance with the receptor for different amounts of time. LSD doesn’t grab a partner as soon as it arrives, but once it starts dancing, it really embraces the receptor and dances for a long time.”

According to Baggott, classical psychedelics like LSD and psilocybin, the active compound in magic mushrooms, have high physiological safety, as long as one doesn’t take dramatic overdoses. “Combining them in reasonable doses is usually also physiologically safe,” he said.

You can’t say that about all drugs—mixing different types of opioids, for example, can be deadly. But there just isn’t that much data to be sure yet what the long-term mental health effects of mixing psychedelics could be.

In the ‘60s, doctors giving people doses of two different psychedelics wasn’t unheard of, before ethical standards in science made institutional review boards unlikely to approve such research.

This Is What Happens When You Take 550 Doses of LSD At Once

For example, in 1964 two researchers at Stanford University, funded by a grant from the National Institute of Health, gave 24 men ages 21 to 40 white capsules containing three different psychedelics: mescaline, psilocybin and LSD. At some point, patients were given a blend of all three, which the researchers noted “appeared to produce an additive effect, the intensity and quality of the clinical syndrome being comparable to full doses of either drug alone.” That is, adding most psychedelics to LSD seems to be fairly synergistic – they produce a combined effect that is greater than the sum of their separate effects.

Important for taking any substance are set and setting, or being comfortable in your brain and body while tripping in a safe place. “If there is something wrong with your physical or mental setting, mixing psychedelics can enhance all those bad things,” said Ivan Romano, co-founder and co-director at Drugs and Me, a harm reduction research group based in the U.K. “It can take you to a very bad place.”

LSD and alcohol or Xanax

When coming down from a trip, some people might want something to take the edge off. So it’s not uncommon to mix LSD with depressant drugs such as alcohol or benzodiazepines like Xanax, that slow down the nervous system. But this combo can quickly become life-threatening.

“Depressants are very dose-sensitive, so if you take too much you quickly get into dangerous doses,” Romano said. Plus, you’re more at risk of losing your balance and other accidents. “When you mix these two drugs you have the clumsiness of one and all the perceptual distortion of the other. So the risk of injuries and accidents is much higher.”

According to some reports, LSD and alcohol do not synergize together well. “Alcohol tends to mute the effects of LSD more than anything. It just doesn’t work as well,” according to Mitchell Gomez, executive director of DanceSafe, a nonprofit drug education group. This can encourage people to take more LSD, but when the alcohol wears off, you can still be tripping for hours, way more than intended.

“That’s a really sort of nasty spiral you could get into, trying to balance those two substances,” Gomez said. “I’ve actually seen somebody end up in the hospital just from straight alcohol poisoning because of that combination.”

LSD and antidepressants

There are so many different kinds of antidepressants on the market, each with unique biochemical interactions, it can be hard to sum up how they will make a single person feel, let alone by throwing LSD into the equation. However, when acid was first being explored as a psychiatric tool in the ‘50s and ‘60s, many clinical trials combined LSD with an antidepressant. With some antidepressant drug classes, such as SSRIs or MAOIs, the effects of LSD are diminished or don’t come on at all.

For example, in 1964 a researcher named Oscar Resnick at the Worcester Foundation for Experimental Biology in Massachusetts gave four men a small dose of LSD, between 40 and 75 micrograms. All four men had been taking isocarboxazid, an MAOI, for several weeks.

Resnick reported the “experiences produced by LSD-25 were either very markedly attenuated [reduced] or did not develop at all.” A year later, this experiment was reproduced by famed LSD researcher Stanislav Grof, who gave acid to 11 patients taking an MAOI called nialamide. Even doses as high as 400 micrograms failed to produce much and the resistance lasted as long as two weeks after the antidepressant was discontinued.

SSRIs seem to have a similar effect, though the research is also very limited. In a 1996 survey, 28 out of 32 people who took SSRIs and LSD experienced “subjective decrease or virtual elimination” of the trippy effects. It’s theorized that the reason for this cross-tolerance could be that LSD and drugs like Zoloft are influencing the same serotonin receptors in the brain, although in slightly different ways. The competition can diminish the effects of the acid, but it may work differently for other antidepressants.

In contrast, the authors of that survey had previously surveyed ten men, some of whom had taken tricyclic antidepressants. This unique class of antidepressant reportedly made some LSD trips more potent, not less. Users reported “more psychic energy” and “somatic distortion” from the combo, with livelier, perkier, and more elaborated hallucinations, such as seeing the sunrise for over an hour in the middle of the night. Some of these same users reported that after they stopped taking drugs like desipramine or clomipramine, their LSD trips weren’t as strong.

From that same survey, users who took lithium, a different class of antidepressant, also had more intense trips from LSD, but they weren’t pleasant. One subject was so over-stimulated it made for a “tedious and trying experience,” according to the report, while “one subject also experienced auditory hallucinations that were self-critical, accompanied by the inability to form words, both of which had never happened to him before.” These surveys relied on user self-reports, so they aren’t the most reliable sources, but they’re also some of the only research on the subject.

LSD and weed

Cannabis generally blends with most recreational drugs in a positive way, as it’s relatively non-toxic, the effects are manageable for most people and it usually wears off within a few hours. But combining it with LSD is a polarizing activity. Some people love the combo, others hate it, perhaps because the effects can sometimes be unpredictable.

“Smoking cannabis on LSD seems to potentiate the effects of both, so you end up with a sort of stronger effect of both substances,” said Gomez. LSD and weed are synergistic, which means marijuana can make hallucinogenic visuals more intense. It can make you start tripping again if you smoke it as you start to come down.

“It’s actually almost a joke within some psychedelic communities, a sort of classic mistake as you’re coming down off of LSD to be like, ‘Oh, I’m gonna smoke some pot and go to bed and then you do and now you’re like tripping tripping again,” Gomez said. If you’re not expecting that, it can be an overwhelming, uncomfortable experience.

LSD and stimulants

Speed, cocaine and Adderall energize the nervous system and escalate heart rate. LSD can also increase your heart rate, putting extra strain on your cardiovascular system, which could put you at risk for heart attack or stroke. This may not be an issue at manageable doses, but you may end up doing more of a drug than you intended. “When you mix these two drugs there’s a risk of losing track of what you’re doing and then ending up taking too much,” Romano said.

“Back in the 1950s, when therapists were first exploring LSD psychotherapy,” said Baggot, “it was pretty common to give a stimulant as well. It seemed to improve moods and make patients more communicative. Amphetamines do have safety concerns, particularly when they’re used without medical supervision. Higher doses can increase blood pressure and body temperature, and cause brain oxidative stress. Combining LSD and amphetamines increases all these safety concerns.”

Mixing the two can be overstimulating, which might cause anxiety or panic. Adding coke to LSD reportedly kills the pleasurable, trippy aspects of acid, or makes the experience “weird,” so some people avoid it.

Gomez stresses that if you ever plan to combine any two or more drugs together, do as much research as you can, and do it sober. “You don’t want to decide five hours into an LSD trip that you’re gonna try a new drug,” he explained. “That happens pretty often, somebody’s like, ‘Oh, we’re coming down, do you want to snort X, Y or Z?’ That can certainly lead to experiences that people really enjoy and are thankful for. It can also do the opposite. That’s probably a decision you want to make on a clear head.”

Another major issue with mixing any illegal drug is knowing what it actually is. Street drugs are often sold as something they’re not. For example, a hallucinogenic drug called 25I-NBOMe is often sold on blotter paper, resembling LSD. And while there has never been a recorded human death solely caused by taking acid, there have been dozens of deaths attributed to 25I and related compounds.

Despite being relatively non-toxic, LSD is powerful and mixing it with other drugs can be a risky ride.