Categories
BLOG

opium and weed

Combining opioids and marijuana may be advantageous for pain sufferers

Study suggests using the two drugs together could reduce risk of dependency without causing cognitive problems

Researchers report combining cannabinoids with morphine did not significantly increase impulsivity or memory impairment in a study conducted in rhesus monkeys. The findings suggest using opioids and marijuana together could offer a safe way to cut opioid dosage among patients suffering from pain and thereby reduce their risk of becoming addicted to opioids.

“These data provide additional evidence supporting the notion that opioid-cannabinoid mixtures that are effective for treating pain do not have greater, and in some cases have less, adverse effects compared with larger doses of each drug alone,” said Vanessa Minervini, PhD, a postdoctoral fellow at the University of Texas Health Science Center at San Antonio.

Minervini will present the research at the American Society for Pharmacology and Experimental Therapeutics annual meeting during the 2019 Experimental Biology meeting, held April 6-9 in Orlando, Fla.

Previous studies have suggested the cannabinoids in marijuana enhance some of the pain-relieving effects of opioid drugs but do not enhance effects related to addiction and overdose. However, both drugs individually are known to slightly impair cognition, leading to a concern that such side effects could be amplified if opioids and marijuana are used together. Researchers say the new study offers encouraging evidence this is not the case.

The research comes amid a national opioid abuse crisis in which many addictions start with opioids prescribed for pain. At the same time, marijuana use is on the rise as more states legalize the drug for medical or recreational use.

“The current opioid epidemic underscores the need for safe and effective pharmacotherapies for treating pain,” said Minervini. “Combining opioid receptor agonists with drugs that relieve pain through actions at non-opioid mechanisms (for example, cannabinoid receptors) could be a useful strategy for reducing the dose of opioid needed to achieve pain relief.”

The researchers gave several monkeys moderate doses of morphine and CP55940, a synthetic drug that mimics the activity of the tetrahydrocannabinol (THC) naturally found in marijuana. They assessed impulsivity and memory with tests involving touchscreens and treats. The results showed each drug impeded performance and that giving the monkeys both drugs together had a lower effect on performance than either drug alone.

While clinical trials would need to be conducted to confirm whether these results translate to humans, monkeys tend to process drugs similarly to humans and are considered a good model for cognition.

Researchers report combining cannabinoids with morphine did not significantly increase impulsivity or memory impairment in a study conducted in rhesus monkeys. The findings suggest using opioids and marijuana together could offer a safe way to cut opioid dosage among patients suffering from pain and thereby reduce their risk of becoming addicted to opioids.

Opium and weed

Queen of Plants… We call her Opium. Yes, the Queen of Paradise plants is a bold claim but one we are confident to make. This sativa/indica mix combines a majestic grow with a deliciously regal smoke.

As you would expect with our Queen, we invested much time and energy into her preparation. By the time she stepped into the limelight she had been bred over several generations, using the genetics of original classic lines; and she didn’t disappoint when she arrived. A High Times Cannabis Cup prize winner, Opium was an instant hit with the growing community.

The characteristics we channeled into Opium have created a strain with stand out qualities. The plant grows strong, with a thick stem and bushy side branches. This gives it the tools to produce BIG and heavy buds that are trichome rich.

A pleasure to work with for the indoor gardener (60 days flower time), this sturdy plant is versatile. It can be grown as a multi branch, stand alone, or in a set up that employs a Sea Of Green as it responds very well to training. Particularly impressive results have been achieved by those who use hydroponic systems, and hydro growers are big fans of its easy management too.

Outside, the Opium is a different story. In a warm and sunny climate it will grow more tree than bush, which makes it particularly effective for growers in southern regions of France, Spain and California.

Although this is a sturdy plant, the big buds may not make it so reliable for garden and guerrilla plots in northern areas, particularly if autumn is wet in your region.

Apart from the regal qualities she displays while growing, Opium carries her majesty through to the finished product. The smoke, fuelled by the plant’s sativa heritage, delivers a swift take-off while the indica factor ensures that the intensity of the experience carries right through to landing. The dominant fragrance is fruit, and the taste is creamy. A little like your favorite cocktail, you will be coming back for more.

Majestic to grow, delicious to inhale, this High Times Cannabis cup winner is a prize plant that rewards big and smokes with a full fruit